天然产物的结构修饰与改造，以及基于活性天然产物骨架的小分子抗肿瘤药物的发现与研究。

本科生：《天然药物化学》及《天然药物化学实验》、《波谱解析》

研究生：《复杂天然产物波谱解析》、《药物结构解析》。

天然产物的结构修饰与改造，以及基于活性天然产物骨架的小分子抗肿瘤药物的发现与研究。

1. He XY, Liu CY, Ding XY, Lin Q, Leng JF, Xiao CM, Zang X, Wang MY, Yin Y, Kong LY, Xia YZ. KY216-tubulin complex captures VASH2 to inhibit NSCLC metastasis. Nat Commun. 2025,17(1):191.

2. Leng J, Zhao Y, Zhao S, Xie S, Sheng P, Zhu L, Zhang M, Chen T, Kong L, Yin Y. Discovery of Novel Isoquinoline Analogues as Dual Tubulin Polymerization/V-ATPase Inhibitors with Immunogenic Cell Death Induction. J Med Chem. 2024,67(4):3144-3166.

3. Chen T, Leng J, Tan J, Zhao Y, Xie S, Zhao S, Yan X, Zhu L, Luo J, Kong L, Yin Y. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023,66(14):10036-10059.

4. Leng J, Zhao Y, Sheng P, Xia Y, Chen T, Zhao S, Xie S, Yan X, Wang X, Yin Y, Kong L. Discovery of Novel N-Heterocyclic-Fused Deoxypodophyllotoxin Analogues as Tubulin Polymerization Inhibitors Targeting the Colchicine-Binding Site for Cancer Treatment. J Med Chem. 2022,65(24):16774-16800.

5. Ning M, Zhao B, Cao T, Wu J, Zhang C, Kong L, Luo J, Yin Y. Discovery of novel benzylaniline derivatives containing chloroacetamide as GPX4 inhibitors with potential efficacy in triple-negative breast cancer. Eur J Med Chem. 2025,300:118189.