代谢性肝脏疾病新靶点发现

肿瘤分子药理学

中药及天然活性分子抗肝病研究

科研项目：

1、国家自然科学基金青年项目

2、江苏省自然科学基金青年项目

3、中国博士后科学基金第17批特别资助

4、江苏省卓越博士后计划

5、91porn 基本科研业务费自然科学类重点项目

科研成果：

1.Yanqiu Zhang#, Shengtao Ye#, Weijia Lu, Jiawen Zhong, Yingrong Leng, Ting Yang, Jun Luo, Wenjun Xu, Hao Zhang*, Lingyi Kong*. RNA helicase DEAD-box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling [J]. Hepatology, 2023, 77(5): 1670−1687.

2. Hao Zhang#, Yanqiu Zhang#, Xiaoyun Zhu, Chen Chen, Chao Zhang, Yuanzheng Xia, Yucheng Zhao, Ourania Andrisani, Lingyi Kong*. DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1 [J]. Hepatology, 2019, 69(3), 1046−1063.

3. Yanqiu Zhang#, Ruirui Dong#, Huiling Zhou, Jingyi Wang, Jianfei Shi, Shengtao Ye, Yang Cheng, Yingrong Leng, Wenjun Xu*, Lingyi Kong*, Hao Zhang*. The flavonoid glycoside from Abrus cantoniensis Hance alleviates alcoholic liver injury by inhibiting ferroptosis in an AMPK-dependent manner [J]. Journal of Agricultural and Food Chemistry, 2024, 72(29): 16323−16333.

4. Yingrong Leng#, Yanqiu Zhang#, Yang Cheng, Shengtao Ye, Ying Zheng, Mengmeng He, Enyi Wu, Lingyi Kong*, Hao Zhang*. LIX1L aggravates MASH-HCC progression by reprogramming of hepatic metabolism and microenvironment via CD36 [J]. Pharmacological Research, 2025, 211, 107567.

5. Mingzhu Han, Yang Cheng, Wenli Wang, Shengtao Ye, Lingyi Kong*, Yanqiu Zhang*, Hao Zhang*. Nodosin alleviates cholestatic liver injury by activation of SIRT1/FXR signaling pathway and inhibition of hepatic inflammation [J]. Biochemical Pharmacology, 2025, 242, 117200.